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Biochemistry CoursesFor Distribution Requirement purposes, all BCH courses are classified as SCIENCE courses. Bioinformatics & Computational Biology CoursesSee page 32 for Key to Course Descriptions.For Distribution Requirement purposes, all BCB courses are classified as SCIENCE courses (see page 26). For details on BCB courses, see www.biochemistry.utoronto.ca/bcb BCB410H1
Applied Bioinformatics [26L, 13P] BCB420H1
Computational Systems Biology [26L] BCB430Y1
Special Project in Bioinformatics and Computational Biology [TBA] Biochemistry CoursesBCH299Y1 Credit course for supervised participation in faculty research project. See page 48 for details. BCH210H1 Proteins, enzymes, membranes and the metabolism of carbohydrates and
lipids. This course is intended for students who are NOT taking BCH 242Y1 as
part
of their program. NOTE: CHM1** WITH COURSE EXCLUSION TO CHM138H AND CHM139H meet the prerequisite requirement for BCH210H. SCI1** DOES NOT COUNT AS A PREREQUISITE. CHM140Y1 (UTM) is equivalent to CMH139H1 ONLY. Students that have an SDF for CHM138/139 are not permitted to take BCH210H1 until a final mark appears on the transcript. An introduction to biochemistry for students
specializing in biochemistry and related specialist programs. The
major topics
include protein structure,
enzyme
mechanisms, carbohydrates, metabolism and bioenenergetics, lipids,
membranes, structure of DNA and RNA. BCH304H1 Principles and concepts of cell biology; structure,
molecular organization and dynamic cell-cell and cell-extracellular
matrix interactions during
cell migration, cell adhesion, cell polarity and tissue organization
and the role
of cytoskeletal components and cell surface receptors in these processes.
Approaches and imaging techniques used; contributions of cell biology
to advances in medicine.
cGPA of 2.5 is required for non-Biochemistry Major and Specialists. BCH311H1 Nucleic acids and flow of information in biological
systems. Information storage and transmission by nucleic acids,
as well as new molecular
technologies will
be discussed. BCH335H1 Structure of DNA and RNA. Catalytic RNAs (ribozymes).
Aspects of DNA topology and chromatin structure. Restriction/modification
and fundamentals
of recombinant
DNA technology. BCH340H1 Proteins are the main functional units of the
cell. In this course, a detailed overview of protein structure,
stability, folding, and
protein-ligand interactions
will be given with strong emphasis on discussing the basic principles
in the field. Biophysical methods as well as theoretical approaches
to
studying
protein
stability and folding will be pre-sented. Finally, proteomics approaches
to map protein-protein interactions will be discussed. Priority
will be given to students in the specialist programs listed in
the Arts & Science
Registration Handbook & Timetable.
This course reinforces theoretical principles
through experiments that encompass pH and buffers, spectrophotometry,
chromatography,
electrophoresis
and enzyme
kinetics. Intended for students who are not proceeding further
in biochemistry. It is highly recommended that students take
this course
in their third
year as space is limited and priority will go to third-year
students. cGPA of
2.5 is required for non-Biochemistry Major and Specialists. BCH371H1 An introduction to laboratory techniques of modern
biochemistry. Experiments illustrate and develop the concepts described
in lecture courses, and
prepare the student for advanced training in biochemical
laboratory techniques. (Enrolment limited) Note Students who have completed University of Toronto at Mississauga’s CHM361H5 and 362H5 may enroll in 400-series lecture courses if they obtain permission of the Department BCH422H1 Structural features of membrane proteins and
methods of analysis. Function of membrane proteins as transporters,
channels, pumps and receptors. Molecular
aspects of disease processes linked to membrane proteins. BCH425H1 Theory and practice of modern biophysical techniques
as applied in the study of structure and function of macromolecules;
emphasis on protein
X-ray crystallography,
NMR, and other spectroscopic methods; discussion of selected examples. BCH426H1 A variety of questions relating to signal transduction
are investigated. How is calcium regulated in the cell and how
does calcium regulate
cell function? How are extracellular signals received and transmitted
by intracellular
proteins
to control cellular prolifera-tion and differentiation? What signaling
paths are triggered by insulin? BCH427H1 This course provides a focused study of concepts
in thermodynamics, statistical mechanics and quantum mechanics
through examples dealing
with important
current problems in molecular biophysics. Concepts in thermodynamics
and statistical
mechanics will be surveyed through applications to protein folding,
while principles of quantum mechanics will be emphasized through
a study of
nuclear magnetic
resonance spectroscopy. JBI428H1 Molecular mechanisms involved in innate and adaptive
immunity including the structure and function of immunoglobulins,
the complement system,
antigen processing and presentation and membrane signalling events.
Emphasis is
on
experimental
approaches and quantitative aspects. (Given jointly by the Departments
of Biochemistry and Immunology) BCH440H1 Mechanisms of translation initiation and translational
control, ribosome assembly and structure. Protein folding and molecular
chaperones.
Protein targeting
and transport. Regulation of protein degradation. BCH441H1 This course covers computational methods and
internet resources in modern biochemistry and molecular biology.
The main topics include:
sequence
and genome databases,
sequence alignment and homology search, use and interpretation
of
molecular structure, and phylogenetic analysis. Assignments focus
on competence
building with essential, web-based bioinformatics tools. Tutorials
are optional
and will be offered based on needs. BCH444H1 This course examines the molecular details of
the secretory and endocytic pathways in the cell. Some of the specific
topics covered
will include
protein translocation
into the ER, chaperones and protein folding in the ER, retrotranslocation
and protein degradation, the Unfolded Protein Response (UPR),
vesicle biogenesis and ER-Golgi transport, regulated secretion,
basic concepts
in endocytosis
and protein sorting in polarized cells. BCH445H1
Principles and concepts of cell biology are covered
including structure, biogenesis, and dynamic behaviour of cell
organelles.
The roles
of sub-nuclear structure
in DNA replica-tion and of vesicular transport in endocytosis,
exocytosis and phagocytosis are empha-sized, as are modern
imaging techniques
and contributions of cell biology to advances in medicine. BCH471Y1
Experiments demonstrating modern concepts of
biochemistry and molecular biology. (Enrol-ment limited) BCH473Y1 Research in a particular area of biochemistry,
by arrangement with the Department and the instructor concerned.
Students must have
a minimum GPA of 3.0. |